Assay Detail
Functional
CHEMBL4610985
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Antiproliferative activity against human UM-UC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UMUC3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and anti-proliferative mechanism of fluorine-containing proguanil derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.11 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4638371 | — | — | 1 | 5.70 |
| CHEMBL4647433 | — | — | 1 | 5.68 |
| CHEMBL4648028 | — | — | 1 | 5.48 |
| CHEMBL4635269 | — | — | 1 | 5.31 |
| CHEMBL4637733 | — | — | 1 | 5.28 |
| CHEMBL4634231 | — | — | 1 | 5.16 |
| CHEMBL4641205 | — | — | 1 | 5.15 |
| CHEMBL4647088 | — | — | 1 | 5.14 |
| CHEMBL1377 | PROGUANIL | 4.0 | 1 | 4.79 |
| CHEMBL4637684 | — | — | 1 | 4.76 |
| CHEMBL4635182 | — | — | 1 | 4.74 |
| CHEMBL4635458 | — | — | 1 | 4.66 |
| CHEMBL4648079 | — | — | 1 | 4.60 |
| CHEMBL4632354 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4638371 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4647433 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4648028 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4635269 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4637733 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4634231 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4641205 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4647088 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1377 | PROGUANIL | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4637684 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4635182 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4635458 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4648079 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4632354 | — | IC50 | > | 50000.0 | nM | - |