Assay Detail
ADMET
CHEMBL4611015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human CRL1790 cells assessed as inhibition of cell growth
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | CCD-841CoN |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel hybrid molecules of 3,5-bis(benzylidene)-4-piperidones and dichloroacetic acid which demonstrate potent tumour-selective cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.87 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4643807 | — | — | 1 | 5.04 |
| CHEMBL154716 | — | — | 1 | 5.03 |
| CHEMBL4643806 | — | — | 1 | 4.97 |
| CHEMBL4645527 | — | — | 1 | 4.96 |
| CHEMBL4637241 | — | — | 1 | 4.96 |
| CHEMBL4644654 | — | — | 1 | 4.96 |
| CHEMBL4644164 | — | — | 1 | 4.91 |
| CHEMBL4644692 | — | — | 1 | 4.90 |
| CHEMBL306823 | SODIUM DICHLOROACETATE | 3.0 | 1 | 4.90 |
| CHEMBL4637754 | — | — | 1 | 4.88 |
| CHEMBL4633726 | — | — | 1 | 4.86 |
| CHEMBL4638546 | — | — | 1 | 4.84 |
| CHEMBL4639410 | — | — | 1 | 4.83 |
| CHEMBL4637045 | — | — | 1 | 4.83 |
| CHEMBL4644904 | — | — | 1 | 4.82 |
| CHEMBL4636732 | — | — | 1 | 4.79 |
| CHEMBL4635647 | — | — | 1 | 4.79 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.73 |
| CHEMBL1993449 | — | — | 1 | 4.68 |
| CHEMBL4643361 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4643807 | — | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL154716 | — | IC50 | = | 9450.0 | nM | 5.03 |
| CHEMBL4643806 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4645527 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4637241 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4644654 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4644164 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4644692 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL306823 | SODIUM DICHLOROACETATE | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4637754 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4633726 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4638546 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4639410 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4637045 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4644904 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4636732 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4635647 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL1993449 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL4643361 | — | IC50 | = | 21100.0 | nM | 4.68 |