Assay Detail
Binding
CHEMBL4611294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.75 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645971 | — | — | 1 | 4.75 |
| CHEMBL4637126 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645971 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4637126 | — | IC50 | > | 40000.0 | nM | - |