Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4611575

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Neuroprotective activity against CoCl2-induced neuronal injury in rat PC12 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Cell Type PC-12
Confidence 1 — Organism
Curated By Autocuration

Target

PC-12 (CHEMBL612556)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Application of tandem biotransformation for biosynthesis of new pentacyclic triterpenoid derivatives with neuroprotective effect.
Xu SH, Chen HL, Fan Y, Xu W, Zhang J.
Bioorg Med Chem Lett (2020) 30 : 126947 -126947
PubMed 31924497 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 5.83 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL465208 SALIDROSIDE 1 6.68
CHEMBL4635231 1 6.32
CHEMBL230006 ENOXOLONE 2.0 1 6.05
CHEMBL4644680 1 5.75
CHEMBL4646750 1 5.11
CHEMBL168 OLEANOLIC_ACID 1 5.07
CHEMBL4647592 1 -
CHEMBL4644678 1 -
CHEMBL4640932 1 -
CHEMBL4633875 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL465208 SALIDROSIDE EC50 = 210.0 nM 6.68
CHEMBL4635231 EC50 = 480.0 nM 6.32
CHEMBL230006 ENOXOLONE EC50 = 890.0 nM 6.05
CHEMBL4644680 EC50 = 1760.0 nM 5.75
CHEMBL4646750 EC50 = 7740.0 nM 5.11
CHEMBL168 OLEANOLIC_ACID EC50 = 8550.0 nM 5.07
CHEMBL4647592 EC50 > 40000.0 nM -
CHEMBL4644678 EC50 > 40000.0 nM -
CHEMBL4640932 EC50 > 40000.0 nM -
CHEMBL4633875 EC50 > 40000.0 nM -