Assay Detail
Binding
CHEMBL4611596
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Inhibition of GSK3 (unknown origin) using CREB peptide as substrate
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.39 | 8.30 |
| EC50 | 1 | 6.11 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647324 | — | — | 1 | 8.30 |
| CHEMBL1242830 | — | — | 1 | 8.10 |
| CHEMBL4645243 | — | — | 1 | 7.96 |
| CHEMBL4649659 | — | — | 1 | 7.96 |
| CHEMBL4636986 | — | — | 1 | 7.92 |
| CHEMBL4644060 | — | — | 1 | 7.89 |
| CHEMBL4644888 | — | — | 1 | 7.89 |
| CHEMBL4644014 | — | — | 1 | 7.89 |
| CHEMBL4635530 | — | — | 1 | 7.82 |
| CHEMBL4649593 | — | — | 1 | 7.75 |
| CHEMBL4642372 | — | — | 1 | 7.54 |
| CHEMBL4637210 | — | — | 1 | 7.44 |
| CHEMBL4639648 | — | — | 1 | 7.36 |
| CHEMBL4635592 | — | — | 1 | 7.28 |
| CHEMBL4643626 | — | — | 1 | 7.24 |
| CHEMBL4635565 | — | — | 1 | 7.18 |
| CHEMBL4645239 | — | — | 1 | 7.16 |
| CHEMBL4649815 | — | — | 1 | 7.13 |
| CHEMBL4647951 | — | — | 1 | 6.70 |
| CHEMBL4638891 | — | — | 1 | 6.68 |
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 6.11 |
| CHEMBL4636121 | — | — | 1 | 6.00 |
| CHEMBL4637962 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647324 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1242830 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4645243 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4649659 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4636986 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4644060 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4644888 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4644014 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4635530 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4649593 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4642372 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4637210 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4639648 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4635592 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4643626 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4635565 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4645239 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4649815 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4647951 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL4638891 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL412142 | LADUVIGLUSIB | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4636121 | — | IC50 | = | 1012.0 | nM | 6.00 |
| CHEMBL4637962 | — | IC50 | = | 3700.0 | nM | 5.43 |