Assay Detail
Binding
CHEMBL4611597
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Inhibition of GSK3 in CHO cells expressing insulin receptor assessed as activation of glycogen synthase measured after 30 mins in presence of glucose-6-phosphate by filter paper assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.34 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644888 | — | — | 1 | 7.40 |
| CHEMBL4644014 | — | — | 1 | 7.16 |
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 6.89 |
| CHEMBL1242830 | — | — | 1 | 6.89 |
| CHEMBL4645243 | — | — | 1 | 6.85 |
| CHEMBL4635530 | — | — | 1 | 6.66 |
| CHEMBL4635592 | — | — | 1 | 6.54 |
| CHEMBL4637210 | — | — | 1 | 6.51 |
| CHEMBL4649659 | — | — | 1 | 6.29 |
| CHEMBL4647324 | — | — | 1 | 6.28 |
| CHEMBL4639648 | — | — | 1 | 6.12 |
| CHEMBL4643626 | — | — | 1 | 6.12 |
| CHEMBL4635565 | — | — | 1 | 5.98 |
| CHEMBL4645239 | — | — | 1 | 5.97 |
| CHEMBL4642372 | — | — | 1 | 5.87 |
| CHEMBL4644060 | — | — | 1 | 5.85 |
| CHEMBL4636986 | — | — | 1 | 5.80 |
| CHEMBL4649593 | — | — | 1 | 5.75 |
| CHEMBL4649815 | — | — | 1 | 5.52 |
| CHEMBL4637962 | — | — | 1 | - |
| CHEMBL4647951 | — | — | 1 | - |
| CHEMBL4638891 | — | — | 1 | - |
| CHEMBL4636121 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644888 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4644014 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL412142 | LADUVIGLUSIB | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1242830 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4645243 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4635530 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4635592 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4637210 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4649659 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4647324 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4639648 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4643626 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4635565 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4645239 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4642372 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4644060 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4636986 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4649593 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4649815 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4637962 | — | EC50 | - | — | - | |
| CHEMBL4647951 | — | EC50 | - | — | - | |
| CHEMBL4638891 | — | EC50 | - | — | - | |
| CHEMBL4636121 | — | EC50 | - | — | - |