Assay Detail
Binding
CHEMBL4611857
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Inhibition of CDK7/cyclin H/MNAT1 (unknown origin) pre incubated up to 60 mins followed by substrate and ATP addition
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.28 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3128043 | PF-03758309 | 1.0 | 1 | 8.15 |
| CHEMBL4434871 | — | — | 1 | 8.12 |
| CHEMBL4450322 | — | — | 1 | 8.01 |
| CHEMBL4303287 | — | — | 1 | 7.86 |
| CHEMBL4436535 | — | — | 1 | 7.64 |
| CHEMBL4582951 | — | — | 1 | 7.08 |
| CHEMBL4441405 | — | — | 1 | 6.95 |
| CHEMBL3603847 | — | — | 1 | 6.62 |
| CHEMBL4163879 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3128043 | PF-03758309 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4434871 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4450322 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4303287 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL4436535 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4582951 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4441405 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3603847 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL4163879 | — | IC50 | = | 8500.0 | nM | 5.07 |