Assay Detail
Binding
CHEMBL4612465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SERCA1 in NewZealand rabbit skeletal muscle SR vesicles using ATP as substrate incubated for 2 mins followed by Ca2+ addition by NADH coupled enzyme assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Cell Type | SR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (CHEMBL4693) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Phenolic Compounds from <i>Morus nigra</i> Regulate Viability and Apoptosis of Pancreatic β-Cells Possibly via SERCA Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.53 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4648427 | — | — | 1 | 4.72 |
| CHEMBL4637788 | — | — | 1 | 4.61 |
| CHEMBL4173326 | — | — | 1 | 4.53 |
| CHEMBL1096940 | — | — | 1 | 4.45 |
| CHEMBL464006 | MORUSIN | — | 1 | 4.36 |
| CHEMBL380456 | (+/-)-MORACIN P | — | 1 | - |
| CHEMBL205924 | MORACIN O | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4648427 | — | IC50 | = | 18880.0 | nM | 4.72 |
| CHEMBL4637788 | — | IC50 | = | 24560.0 | nM | 4.61 |
| CHEMBL4173326 | — | IC50 | = | 29430.0 | nM | 4.53 |
| CHEMBL1096940 | — | IC50 | = | 35620.0 | nM | 4.45 |
| CHEMBL464006 | MORUSIN | IC50 | = | 43570.0 | nM | 4.36 |
| CHEMBL380456 | (+/-)-MORACIN P | IC50 | - | — | - | |
| CHEMBL205924 | MORACIN O | IC50 | - | — | - |