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Assay Detail

CHEMBL4612759

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Functional
Antiproliferative activity against human HAP1 cells measured after 72 hrs by Celltiter glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HAP1
Confidence 1 — Organism
Curated By Autocuration

Target

HAP1 (CHEMBL4630777)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.
Liu Y, Hao M, Leggett AL, Gao Y, Ficarro SB, Che J, He Z, Olson CM, Marto JA, Kwiatkowski NP, Zhang T, Gray NS.
J Med Chem (2020) 63 : 6708 -6726
PubMed 32502343 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.99 7.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4647764 1 7.99

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4647764 IC50 = 10.15 nM 7.99