Assay Detail
Binding
CHEMBL4613377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.73 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1235529 | — | — | 1 | 6.85 |
| CHEMBL319467 | — | — | 1 | 6.60 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | - |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1235529 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL319467 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3545110 | RIBOCICLIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL3301610 | ABEMACICLIB | IC50 | > | 500.0 | nM | - |