Assay Detail
Binding
CHEMBL4613869
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Inhibition of Mycobacterium smegmatis ATCC 607 dihydrofolic reductase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycolicibacterium smegmatis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Insights of synthetic analogues of anti-leprosy agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.35 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 9.74 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 9.46 |
| CHEMBL44211 | — | — | 1 | 9.05 |
| CHEMBL47078 | — | — | 1 | 9.05 |
| CHEMBL4641326 | — | — | 1 | 9.00 |
| CHEMBL4634803 | — | — | 1 | 9.00 |
| CHEMBL4636751 | — | — | 1 | 8.92 |
| CHEMBL4645950 | — | — | 1 | 8.70 |
| CHEMBL4636327 | — | — | 1 | 8.30 |
| CHEMBL4643952 | — | — | 1 | 7.75 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 7.16 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.12 |
| CHEMBL4632755 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL44211 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL47078 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4641326 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4634803 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4636751 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4645950 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4636327 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4643952 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL22 | TRIMETHOPRIM | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL36 | PYRIMETHAMINE | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL4632755 | — | Ki | = | 5100.0 | nM | 5.29 |