Assay Detail
Binding
CHEMBL4614017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.13 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639814 | — | — | 1 | 7.04 |
| CHEMBL4636778 | — | — | 1 | 6.20 |
| CHEMBL4634776 | — | — | 1 | 5.14 |
| CHEMBL4635958 | — | — | 1 | - |
| CHEMBL4636336 | — | — | 1 | - |
| CHEMBL4635589 | — | — | 1 | - |
| CHEMBL4647914 | — | — | 1 | - |
| CHEMBL4643955 | — | — | 1 | - |
| CHEMBL4643380 | — | — | 1 | - |
| CHEMBL4641869 | — | — | 1 | - |
| CHEMBL4642082 | — | — | 1 | - |
| CHEMBL4645184 | — | — | 1 | - |
| CHEMBL4648300 | — | — | 1 | - |
| CHEMBL4649604 | — | — | 1 | - |
| CHEMBL4633748 | — | — | 1 | - |
| CHEMBL4638977 | — | — | 1 | - |
| CHEMBL1373 | MODAFINIL | 4.0 | 1 | - |
| CHEMBL4643859 | — | — | 1 | - |
| CHEMBL4638203 | — | — | 1 | - |
| CHEMBL4648586 | — | — | 1 | - |
| CHEMBL4647526 | — | — | 1 | - |
| CHEMBL4645855 | — | — | 1 | - |
| CHEMBL4634934 | — | — | 1 | - |
| CHEMBL4647200 | — | — | 1 | - |
| CHEMBL4640152 | — | — | 1 | - |
| CHEMBL4640772 | — | — | 1 | - |
| CHEMBL4640372 | — | — | 1 | - |
| CHEMBL4634263 | — | — | 1 | - |
| CHEMBL4647283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639814 | — | IC50 | = | 91.5 | nM | 7.04 |
| CHEMBL4636778 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL4634776 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4635958 | — | IC50 | - | — | - | |
| CHEMBL4636336 | — | IC50 | - | — | - | |
| CHEMBL4635589 | — | IC50 | - | — | - | |
| CHEMBL4647914 | — | IC50 | - | — | - | |
| CHEMBL4643955 | — | IC50 | - | — | - | |
| CHEMBL4643380 | — | IC50 | - | — | - | |
| CHEMBL4641869 | — | IC50 | - | — | - | |
| CHEMBL4642082 | — | IC50 | - | — | - | |
| CHEMBL4645184 | — | IC50 | - | — | - | |
| CHEMBL4648300 | — | IC50 | - | — | - | |
| CHEMBL4649604 | — | IC50 | - | — | - | |
| CHEMBL4633748 | — | IC50 | - | — | - | |
| CHEMBL4638977 | — | IC50 | - | — | - | |
| CHEMBL1373 | MODAFINIL | IC50 | - | — | - | |
| CHEMBL4643859 | — | IC50 | - | — | - | |
| CHEMBL4638203 | — | IC50 | - | — | - | |
| CHEMBL4648586 | — | IC50 | - | — | - | |
| CHEMBL4647526 | — | IC50 | - | — | - | |
| CHEMBL4645855 | — | IC50 | - | — | - | |
| CHEMBL4634934 | — | IC50 | - | — | - | |
| CHEMBL4647200 | — | IC50 | - | — | - | |
| CHEMBL4640152 | — | IC50 | - | — | - | |
| CHEMBL4640772 | — | IC50 | - | — | - | |
| CHEMBL4640372 | — | IC50 | - | — | - | |
| CHEMBL4634263 | — | IC50 | - | — | - | |
| CHEMBL4647283 | — | IC50 | - | — | - |