Assay Detail
Binding
CHEMBL4614136
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Inhibition of human BACE2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.39 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4637426 | — | — | 1 | 8.28 |
| CHEMBL2396989 | LY-2886721 | 1.0 | 1 | 7.99 |
| CHEMBL4643727 | — | — | 1 | 7.66 |
| CHEMBL4636286 | — | — | 1 | 7.36 |
| CHEMBL2333941 | LY-2811376 | 1.0 | 1 | 6.54 |
| CHEMBL4644249 | — | — | 1 | 5.80 |
| CHEMBL4642463 | — | — | 1 | 5.13 |
| CHEMBL4636311 | — | — | 1 | 4.61 |
| CHEMBL4640948 | — | — | 1 | 4.13 |
| CHEMBL4637568 | — | — | 1 | - |
| CHEMBL4637913 | — | — | 1 | - |
| CHEMBL4648644 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4637426 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2396989 | LY-2886721 | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4643727 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4636286 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2333941 | LY-2811376 | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL4644249 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4642463 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL4636311 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL4640948 | — | IC50 | = | 73600.0 | nM | 4.13 |
| CHEMBL4637568 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4637913 | — | IC50 | = | 104000.0 | nM | - |
| CHEMBL4648644 | — | IC50 | > | 100000.0 | nM | - |