Assay Detail
Binding
CHEMBL4614281
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Inhibition of GRP94 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.96 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103879 | GANETESPIB | 3.0 | 1 | 7.42 |
| CHEMBL4647894 | — | — | 1 | 7.31 |
| CHEMBL4647171 | — | — | 1 | 7.27 |
| CHEMBL4641526 | — | — | 1 | 7.11 |
| CHEMBL4635982 | — | — | 1 | 7.11 |
| CHEMBL4639163 | — | — | 1 | 7.05 |
| CHEMBL4635778 | — | — | 1 | 7.02 |
| CHEMBL4648197 | — | — | 1 | 7.00 |
| CHEMBL4648091 | — | — | 1 | 6.76 |
| CHEMBL4638275 | — | — | 1 | 6.72 |
| CHEMBL4641450 | — | — | 1 | 6.72 |
| CHEMBL4636983 | — | — | 1 | 6.71 |
| CHEMBL4649532 | — | — | 1 | 6.68 |
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103879 | GANETESPIB | IC50 | = | 37.7 | nM | 7.42 |
| CHEMBL4647894 | — | IC50 | = | 49.42 | nM | 7.31 |
| CHEMBL4647171 | — | IC50 | = | 54.1 | nM | 7.27 |
| CHEMBL4641526 | — | IC50 | = | 78.01 | nM | 7.11 |
| CHEMBL4635982 | — | IC50 | = | 77.96 | nM | 7.11 |
| CHEMBL4639163 | — | IC50 | = | 88.98 | nM | 7.05 |
| CHEMBL4635778 | — | IC50 | = | 96.2 | nM | 7.02 |
| CHEMBL4648197 | — | IC50 | = | 100.46 | nM | 7.00 |
| CHEMBL4648091 | — | IC50 | = | 174.8 | nM | 6.76 |
| CHEMBL4638275 | — | IC50 | = | 190.22 | nM | 6.72 |
| CHEMBL4641450 | — | IC50 | = | 192.09 | nM | 6.72 |
| CHEMBL4636983 | — | IC50 | = | 197.13 | nM | 6.71 |
| CHEMBL4649532 | — | IC50 | = | 209.28 | nM | 6.68 |
| CHEMBL200102 | PU-H71 | IC50 | = | 300.6 | nM | 6.52 |