Assay Detail
Functional
CHEMBL4614285
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Antiproliferative activity against human PC3 cells by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.67 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103879 | GANETESPIB | 3.0 | 1 | 8.03 |
| CHEMBL4635982 | — | — | 1 | 6.63 |
| CHEMBL4641526 | — | — | 1 | 6.54 |
| CHEMBL4648197 | — | — | 1 | 6.49 |
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 6.44 |
| CHEMBL4639163 | — | — | 1 | 6.34 |
| CHEMBL4647171 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103879 | GANETESPIB | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4635982 | — | IC50 | = | 234.5 | nM | 6.63 |
| CHEMBL4641526 | — | IC50 | = | 285.9 | nM | 6.54 |
| CHEMBL4648197 | — | IC50 | = | 323.7 | nM | 6.49 |
| CHEMBL200102 | PU-H71 | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL4639163 | — | IC50 | = | 459.7 | nM | 6.34 |
| CHEMBL4647171 | — | IC50 | = | 569.0 | nM | 6.25 |