Assay Detail
ADMET
CHEMBL4614398
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Cytotoxicity against human NHBE cells assessed as reduction in cell viability by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.75 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639986 | — | — | 1 | 5.08 |
| CHEMBL4637985 | — | — | 1 | 4.89 |
| CHEMBL4649751 | — | — | 1 | 4.63 |
| CHEMBL4634992 | — | — | 1 | 4.41 |
| CHEMBL4645703 | — | — | 1 | - |
| CHEMBL4645014 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639986 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL4637985 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4649751 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL4634992 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4645703 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4645014 | — | IC50 | > | 40000.0 | nM | - |