Assay Detail
Functional
CHEMBL4614675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of 0.5 uM N-(anthracenylmethyl) homospermidine-induced toxicity in CHOK1 cells assessed as increase in Ant-44-induced reduction in cell growth measured after 48 hrs in presence of amine oxidase suppressor aminoguanidine by MTS assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-K1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| EC50 | 2 | 6.67 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642431 | — | — | 2 | 7.22 |
| CHEMBL4634927 | — | — | 2 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642431 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4634927 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4642431 | — | Activity | - | — | - | |
| CHEMBL4634927 | — | Activity | - | — | - |