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Assay Detail

CHEMBL4614725

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ADMET
Cytotoxicity against CHOK1 cells assessed as reduction in cell viability after 48 hrs by MTS assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Cricetulus griseus
Cell Type CHO-K1
Confidence 1 — Organism
Curated By Autocuration

Target

CHO-K1 (CHEMBL614031)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors.
Massaro C, Thomas J, Ikhlef H, Dinara S, Cronk S, Moots H, Phanstiel O.
J Med Chem (2020) 63 : 2814 -2832
PubMed 32069402 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.10 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4642431 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4642431 IC50 = 8000.0 nM 5.10