Assay Detail
Binding
CHEMBL4614746
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Inhibition of human serine protease factor B catalytic domain (D470 to L764 residues) assessed as inhibition of cleavage cobra venom factor (CVF):Bb complex pre-incubated for 1 hr before addition of C3 by ELISA
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.03 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633437 | — | — | 2 | 5.85 |
| CHEMBL4634827 | — | — | 1 | 5.47 |
| CHEMBL4638836 | — | — | 1 | 5.23 |
| CHEMBL4638349 | — | — | 2 | 5.22 |
| CHEMBL4647985 | — | — | 1 | 5.20 |
| CHEMBL4636550 | — | — | 1 | 5.18 |
| CHEMBL4638325 | — | — | 1 | 5.18 |
| CHEMBL4637130 | — | — | 1 | 5.17 |
| CHEMBL4637156 | — | — | 1 | 5.10 |
| CHEMBL4643155 | — | — | 1 | 5.06 |
| CHEMBL4633534 | — | — | 1 | 4.96 |
| CHEMBL4646654 | — | — | 1 | 4.85 |
| CHEMBL4636547 | — | — | 1 | 4.48 |
| CHEMBL4636124 | — | — | 1 | 4.30 |
| CHEMBL4648708 | — | — | 1 | 4.19 |
| CHEMBL4645983 | — | — | 1 | - |
| CHEMBL4642825 | — | — | 1 | - |
| CHEMBL4638117 | — | — | 1 | - |
| CHEMBL4644797 | — | — | 1 | - |
| CHEMBL4635101 | — | — | 1 | - |
| CHEMBL4638538 | — | — | 1 | - |
| CHEMBL4646117 | — | — | 1 | - |
| CHEMBL4641221 | — | — | 1 | - |
| CHEMBL4638143 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633437 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4634827 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL4638836 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4638349 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4647985 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4636550 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4638325 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4637130 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4637156 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4643155 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4633534 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4633437 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4646654 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4636547 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4636124 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4648708 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4642825 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4638117 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4645983 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4644797 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4635101 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4638538 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4646117 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4638349 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4641221 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4638143 | — | IC50 | > | 100000.0 | nM | - |