Assay Detail
Binding
CHEMBL4614753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formation pre-incubated for 15 mins before activated zymosan A stimulation for 50 mins by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.78 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644208 | — | — | 1 | 6.96 |
| CHEMBL4594448 | IPTACOPAN | 4.0 | 1 | 6.89 |
| CHEMBL4639592 | — | — | 1 | 6.85 |
| CHEMBL4646504 | — | — | 1 | 6.82 |
| CHEMBL4632794 | — | — | 1 | 6.75 |
| CHEMBL4641109 | — | — | 1 | 6.62 |
| CHEMBL4644994 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644208 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4594448 | IPTACOPAN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4639592 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4646504 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4632794 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4641109 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4644994 | — | IC50 | = | 250.0 | nM | 6.60 |