Assay Detail

CHEMBL4614949

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Binding

Reversible inhibition of rat liver S- adenosyl-L-homocysteine hydrolase using SAH as substrate by spectrophotometric method

ChEMBL ↗

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Target

Adenosylhomocysteinase (CHEMBL3118) ↗

Open DB target context

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Adenosylhomocysteinase (CHEMBL3118) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Adenosylhomocysteinase

CHEMBL3118

Anchored from Assay target.

Protein identity Adenosylhomocysteinase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Adenosylhomocysteinase (CHEMBL3118) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.

Johnson BM, Shu YZ, Zhuo X, Meanwell NA.
J Med Chem (2020) 63 : 6315 -6386
PubMed 32182061 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.08	8.08

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL8771	NEOPLANOCIN A	—	1	8.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL8771	NEOPLANOCIN A	Ki	=	8.39	nM	8.08