Assay Detail
Binding
CHEMBL4615151
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Antagonist activity at rat P2X1 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.06 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1253351 | — | — | 1 | 9.55 |
| CHEMBL337395 | — | — | 1 | 8.22 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 6.00 |
| CHEMBL69234 | — | — | 1 | 6.00 |
| CHEMBL190141 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1253351 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL337395 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL265502 | SURAMIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL69234 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL190141 | — | IC50 | = | 3000.0 | nM | 5.52 |