Assay Detail
Binding
CHEMBL4615164
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of collagen-induced platelet aggregation pre-incubated for 30 mins before collagen stimulation by aggregometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.78 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536151 | IMD-0354 | 1.0 | 1 | 6.24 |
| CHEMBL2338696 | — | — | 1 | 5.94 |
| CHEMBL2313113 | — | — | 1 | 5.68 |
| CHEMBL2179173 | — | — | 1 | 5.52 |
| CHEMBL2313133 | — | — | 1 | 5.50 |
| CHEMBL2088014 | — | — | 1 | - |
| CHEMBL2179174 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536151 | IMD-0354 | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2338696 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL2313113 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2179173 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL2313133 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL2088014 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2179174 | — | IC50 | >= | 10000.0 | nM | - |