Assay Detail
Binding
CHEMBL4615166
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Antagonist activity P2X1 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation pre-incubated for 30 mins before ADP stimulation by aggregometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.30 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536151 | IMD-0354 | 1.0 | 1 | 5.33 |
| CHEMBL2338696 | — | — | 1 | 5.26 |
| CHEMBL2313113 | — | — | 1 | - |
| CHEMBL2088014 | — | — | 1 | - |
| CHEMBL2179173 | — | — | 1 | - |
| CHEMBL2179174 | — | — | 1 | - |
| CHEMBL2313133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536151 | IMD-0354 | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL2338696 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL2313113 | — | IC50 | >= | 20000.0 | nM | - |
| CHEMBL2088014 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2179173 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2179174 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2313133 | — | IC50 | > | 20000.0 | nM | - |