Assay Detail
Functional
CHEMBL4615216
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Antiviral activity against HCV J6/JFH/JC1 infected in human Huh7.5 cells assessed as reduction in viral RNA levels incubated for 72 hrs by qRT-PCR analysis
13
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-((4-Arylpiperazin-1-yl)methyl)benzonitrile Derivatives as Orally Available Inhibitors of Hepatitis C Virus with a Novel Mechanism of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.55 | 7.66 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634954 | — | — | 2 | 7.66 |
| CHEMBL4634052 | — | — | 2 | 7.51 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 7.34 |
| CHEMBL4639593 | — | — | 1 | 6.75 |
| CHEMBL4638907 | — | — | 1 | 6.38 |
| CHEMBL4646761 | — | — | 1 | 6.05 |
| CHEMBL4649249 | — | — | 1 | 5.79 |
| CHEMBL4639526 | — | — | 1 | 5.78 |
| CHEMBL4649023 | — | — | 1 | 5.67 |
| CHEMBL4645789 | — | — | 1 | - |
| CHEMBL4649303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634954 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4634052 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4639593 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4638907 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4646761 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4649249 | — | EC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4639526 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4649023 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL4645789 | — | EC50 | > | 66670.0 | nM | - |
| CHEMBL4649303 | — | EC50 | > | 7410.0 | nM | - |
| CHEMBL4634954 | — | Activity | - | — | - | |
| CHEMBL4634052 | — | Activity | - | — | - |