Assay Detail
Binding
CHEMBL4615385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BRD9 (unknown origin) N-terminal bromodomain by TR-FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.33 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644816 | — | — | 1 | 7.20 |
| CHEMBL4633192 | — | — | 1 | 7.00 |
| CHEMBL4645392 | — | — | 1 | 7.00 |
| CHEMBL4643455 | — | — | 1 | 7.00 |
| CHEMBL4646728 | — | — | 1 | 6.70 |
| CHEMBL4648548 | — | — | 1 | 6.70 |
| CHEMBL4645268 | — | — | 1 | 6.40 |
| CHEMBL4639281 | — | — | 1 | 6.10 |
| CHEMBL4647246 | — | — | 1 | 5.90 |
| CHEMBL4095646 | — | — | 1 | 5.70 |
| CHEMBL4642945 | — | — | 1 | 5.60 |
| CHEMBL4093233 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644816 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4633192 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4645392 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4643455 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4646728 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4648548 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4645268 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4639281 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4647246 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4095646 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4642945 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4093233 | — | IC50 | = | 25118.86 | nM | 4.60 |