Assay Detail
Functional
CHEMBL4615580
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Cytotoxicity against human GCE28 cells derived from central tumor core of GBM patient assessed as reduction in cell viability measured after 48 hrs by Prestoblue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of Pyrazolo[3,4-<i>d</i>]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.81 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3394092 | — | — | 1 | 5.14 |
| CHEMBL4638374 | — | — | 1 | 4.97 |
| CHEMBL3578214 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394092 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4638374 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL3578214 | — | IC50 | = | 47600.0 | nM | 4.32 |