Assay Detail
Functional
CHEMBL4615983
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Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.42 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639264 | — | — | 1 | 6.77 |
| CHEMBL1173445 | LARGAZOLE | — | 1 | 6.48 |
| CHEMBL4646139 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639264 | — | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL1173445 | LARGAZOLE | EC50 | = | 331.13 | nM | 6.48 |
| CHEMBL4646139 | — | EC50 | = | 1000.0 | nM | 6.00 |