Assay Detail
Functional
CHEMBL4615985
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Antiproliferative activity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.26 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4646139 | — | — | 1 | 8.25 |
| CHEMBL4639264 | — | — | 1 | 7.42 |
| CHEMBL1173445 | LARGAZOLE | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4646139 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL4639264 | — | EC50 | = | 38.02 | nM | 7.42 |
| CHEMBL1173445 | LARGAZOLE | EC50 | = | 758.58 | nM | 6.12 |