Assay Detail
Functional
CHEMBL4616036
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.36 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636822 | — | — | 1 | 4.58 |
| CHEMBL4648130 | — | — | 1 | 4.44 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.36 |
| CHEMBL4640727 | — | — | 1 | 4.06 |
| CHEMBL4632489 | — | — | 1 | - |
| CHEMBL4646661 | — | — | 1 | - |
| CHEMBL4639000 | — | — | 1 | - |
| CHEMBL4636837 | — | — | 1 | - |
| CHEMBL21708 | 4-METHYLBENZOIC ACID | — | 1 | - |
| CHEMBL4632707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636822 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4648130 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4640727 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL4632489 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4646661 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4639000 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4636837 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL21708 | 4-METHYLBENZOIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL4632707 | — | IC50 | > | 100000.0 | nM | - |