Assay Detail
Functional
CHEMBL4616037
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Cytotoxicity against human Caco2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.49 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.68 |
| CHEMBL4636822 | — | — | 1 | 4.55 |
| CHEMBL4648130 | — | — | 1 | 4.23 |
| CHEMBL4632489 | — | — | 1 | - |
| CHEMBL4646661 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4636822 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4648130 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4632489 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4646661 | — | IC50 | > | 100000.0 | nM | - |