Assay Detail
ADMET
CHEMBL4616347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human C3PV cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.75 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4640102 | — | — | 1 | 6.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.35 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 6.29 |
| CHEMBL4641492 | — | — | 1 | 5.50 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4640102 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4641492 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 78880.0 | nM | 4.10 |