Assay Detail
Functional
CHEMBL4616348
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Cytotoxicity against human RPMI7951 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-7951 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.64 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.89 |
| CHEMBL4641492 | — | — | 1 | 7.30 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.66 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 6.58 |
| CHEMBL4640102 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4641492 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4640102 | — | IC50 | = | 17320.0 | nM | 4.76 |