Assay Detail
Binding
CHEMBL4616478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measuring Kd for AGAGAG + ATP complex formation SPR assay (Rvb = 8 +/- 0.9 microM)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic initiation factor 4A-I (CHEMBL2052028) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.25 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303782 | ZOTATIFIN | 2.0 | 1 | 7.68 |
| CHEMBL438139 | ROCAGLAMIDE | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303782 | ZOTATIFIN | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL438139 | ROCAGLAMIDE | Kd | = | 156.0 | nM | 6.81 |