Assay Detail

CHEMBL4616772

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ADMET

Cytotoxicity against human peripheral B cells assessed as reduction in cell viability

ChEMBL ↗

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Target

B cell (CHEMBL5314312) ↗

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Primary target B cell

CHEMBL5314312

Anchored from Assay target.

Protein identity B cell

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Cell Type	B cell
Confidence	1 — Organism
Curated By	Autocuration

Target

B cell (CHEMBL5314312) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).

Watterson SH, Liu Q, Beaudoin Bertrand M, Batt DG, Li L, Pattoli MA, Skala S, Cheng L, Obermeier MT, Moore R, Yang Z, Vickery R, Elzinga PA, Discenza L, D'Arienzo C, Gillooly KM, Taylor TL, Pulicicchio C, Zhang Y, Heimrich E, McIntyre KW, Ruan Q, Westhouse RA, Catlett IM, Zheng N, Chaudhry C, Dai J, Galella MA, Tebben AJ, Pokross M, Li J, Zhao R, Smith D, Rampulla R, Allentoff A, Wallace MA, Mathur A, Salter-Cid L, Macor JE, Carter PH, Fura A, Burke JR, Tino JA.
J Med Chem (2019) 62 : 3228 -3250
PubMed 30893553 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.40	10.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4297674	BRANEBRUTINIB	2.0	1	10.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4297674	BRANEBRUTINIB	IC50	=	0.04	nM	10.40