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Assay Detail

CHEMBL4616899

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Influenza A virus
Cell Type MDCK
Confidence 1 — Organism
Curated By Autocuration

Target

Influenza A virus (CHEMBL613740)
Type ORGANISM
Organism Influenza A virus

Publication

Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents.
Chintakrindi AS, Gohil DJ, Chowdhary AS, Kanyalkar MA.
Bioorg Med Chem (2020) 28 : 115191 -115191
PubMed 31744778 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 7.61 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL674 OSELTAMIVIR CARBOXYLATE -1.0 1 8.15
CHEMBL16312 4'-METHOXYFLAVONE 1 8.03
CHEMBL64780 1 7.92
CHEMBL342343 1 7.90
CHEMBL291876 1 7.85
CHEMBL16783 1 7.45
CHEMBL611941 4'-METHOXY-AURONE 1 7.45
CHEMBL4634688 1 7.33
CHEMBL56414 1 7.32
CHEMBL596254 1 7.29
CHEMBL50 QUERCETIN 3.0 1 7.07
CHEMBL2253271 1 -
CHEMBL593006 (Z)-2'-METHOXYAURONE 1 -
CHEMBL596255 3'-METHOXY-AURONE 1 -
CHEMBL1172482 1 -
CHEMBL4642131 1 -
CHEMBL147722 1 -
CHEMBL2263102 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL674 OSELTAMIVIR CARBOXYLATE EC50 = 7.1 nM 8.15
CHEMBL16312 4'-METHOXYFLAVONE EC50 = 9.36 nM 8.03
CHEMBL64780 EC50 = 11.93 nM 7.92
CHEMBL342343 EC50 = 12.57 nM 7.90
CHEMBL291876 EC50 = 14.12 nM 7.85
CHEMBL16783 EC50 = 35.9 nM 7.45
CHEMBL611941 4'-METHOXY-AURONE EC50 = 35.28 nM 7.45
CHEMBL4634688 EC50 = 46.32 nM 7.33
CHEMBL56414 EC50 = 47.7 nM 7.32
CHEMBL596254 EC50 = 51.39 nM 7.29
CHEMBL50 QUERCETIN EC50 = 84.46 nM 7.07
CHEMBL2253271 EC50 - -
CHEMBL593006 (Z)-2'-METHOXYAURONE EC50 - -
CHEMBL596255 3'-METHOXY-AURONE EC50 - -
CHEMBL1172482 EC50 - -
CHEMBL4642131 EC50 - -
CHEMBL147722 EC50 - -
CHEMBL2263102 EC50 - -