Assay Detail
Binding
CHEMBL4617152
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Inhibition of recombinant human PARG assessed as mono(ADP-R) release using PAR as substrate measured after 15 mins by HPLC analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights into the active site of poly(ADP-ribose) glycohydrolase using docking modes of 6-hydroxy-3H-xanthen-3-one derivative inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.37 | 4.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1208422 | ROSE BENGAL FREE ACID | 4.0 | 1 | 4.53 |
| CHEMBL1254258 | — | — | 1 | 4.21 |
| CHEMBL5483017 | — | — | 1 | - |
| CHEMBL376503 | — | — | 1 | - |
| CHEMBL1205178 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1208422 | ROSE BENGAL FREE ACID | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL1254258 | — | IC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL5483017 | — | IC50 | = | 120100.0 | nM | - |
| CHEMBL376503 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL1205178 | — | IC50 | = | 105600.0 | nM | - |