Assay Detail
Binding
CHEMBL4617427
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Agonist activity at AhR in human HepG2 cells assessed as induction of CYP1A1 expression after 24 hrs by ethoxyresorufin-O-deethylase assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 9.14 | 9.59 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4646273 | — | — | 2 | 9.59 |
| CHEMBL472031 | — | — | 2 | 8.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4646273 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL472031 | — | EC50 | = | 2.04 | nM | 8.69 |
| CHEMBL4646273 | — | Activity | - | — | - | |
| CHEMBL472031 | — | Activity | - | — | - |