Assay Detail
Functional
CHEMBL4617586
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Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.48 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611361 | — | — | 1 | 7.29 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 6.62 |
| CHEMBL4635140 | — | — | 1 | 6.55 |
| CHEMBL392591 | — | — | 1 | 6.30 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.15 |
| CHEMBL611052 | — | — | 1 | 5.96 |
| CHEMBL15193 | LAPACHOL | — | 1 | - |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611361 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4635140 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL392591 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL611052 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL15193 | LAPACHOL | IC50 | > | 30000.0 | nM | - |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | > | 30000.0 | nM | - |