Assay Detail
Binding
CHEMBL4617610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CLR/RAMP1
19
Total Activities
19
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 (CHEMBL2107838) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.07 | 10.52 |
| Ki | 9 | 9.27 | 10.70 |
| Kb | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4638635 | — | — | 1 | 10.70 |
| CHEMBL207197 | OLCEGEPANT | 2.0 | 1 | 10.52 |
| CHEMBL4635331 | HTL-0022562 | 1.0 | 1 | 10.40 |
| CHEMBL4633407 | — | — | 1 | 9.96 |
| CHEMBL4644508 | — | — | 1 | 9.85 |
| CHEMBL4637301 | — | — | 1 | 9.82 |
| CHEMBL4639133 | — | — | 1 | 9.70 |
| CHEMBL4649671 | — | — | 1 | 9.60 |
| CHEMBL3334624 | BI-44370 | 2.0 | 1 | 9.52 |
| CHEMBL236593 | TELCAGEPANT | 3.0 | 1 | 9.11 |
| CHEMBL4641806 | — | — | 1 | 8.33 |
| CHEMBL3334623 | — | — | 1 | 7.36 |
| CHEMBL4645875 | — | — | 1 | 6.60 |
| CHEMBL4634626 | — | — | 1 | 6.00 |
| CHEMBL4634646 | — | — | 1 | 5.32 |
| CHEMBL196582 | — | — | 1 | 4.77 |
| CHEMBL4643140 | — | — | 1 | - |
| CHEMBL4640176 | — | — | 1 | - |
| CHEMBL4649325 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4638635 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL207197 | OLCEGEPANT | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4635331 | HTL-0022562 | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL4633407 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL4644508 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL4637301 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL4639133 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4649671 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL3334624 | BI-44370 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL236593 | TELCAGEPANT | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL4641806 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3334623 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4645875 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4634626 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4634646 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL196582 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4643140 | — | Ki | = | 0.004 | nM | - |
| CHEMBL4640176 | — | Kb | = | 0.31 | nM | - |
| CHEMBL4649325 | — | Ki | = | 0.007 | nM | - |