Assay Detail
Binding
CHEMBL4617617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human CLR/RAMP1
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 (CHEMBL2107838) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 10.50 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3991065 | ATOGEPANT | 4.0 | 1 | 10.82 |
| CHEMBL2364638 | UBROGEPANT | 4.0 | 1 | 10.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3991065 | ATOGEPANT | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL2364638 | UBROGEPANT | Ki | = | 0.067 | nM | 10.17 |