Assay Detail
Binding
CHEMBL4617678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured every 10 secs for 10 mins by spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.69 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633785 | XERUBORBACTAM | 1.0 | 1 | 8.72 |
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 7.96 |
| CHEMBL4636953 | — | — | 1 | 7.68 |
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | 7.25 |
| CHEMBL4640702 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633785 | XERUBORBACTAM | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1689063 | AVIBACTAM | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4636953 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3317857 | VABORBACTAM | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL4640702 | — | Ki | = | 150.0 | nM | 6.82 |