Assay Detail
Binding
CHEMBL4617684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Escherichia coli AmpC using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometrically analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.84 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633785 | XERUBORBACTAM | 1.0 | 1 | 8.07 |
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 8.00 |
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633785 | XERUBORBACTAM | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL1689063 | AVIBACTAM | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3317857 | VABORBACTAM | Ki | = | 35.0 | nM | 7.46 |