Assay Detail
Binding
CHEMBL4617686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometrically analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Acinetobacter baumannii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.45 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633785 | XERUBORBACTAM | 1.0 | 1 | 9.13 |
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 5.77 |
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633785 | XERUBORBACTAM | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL1689063 | AVIBACTAM | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL3317857 | VABORBACTAM | Ki | > | 40000.0 | nM | - |