Assay Detail
Functional
CHEMBL4618178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human C4-2 cells assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP C4-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.96 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635753 | — | — | 1 | 5.51 |
| CHEMBL4637348 | — | — | 1 | 5.04 |
| CHEMBL4645530 | — | — | 1 | 4.90 |
| CHEMBL4643757 | — | — | 1 | 4.84 |
| CHEMBL4646660 | — | — | 1 | 4.75 |
| CHEMBL4641626 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635753 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4637348 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4645530 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4643757 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4646660 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4641626 | — | IC50 | = | 18600.0 | nM | 4.73 |