Assay Detail
Binding
CHEMBL4619130
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Inhibition FITC-labeled BCoR peptide binding to wild type human BCL6 BTB domain (5 to 129 residues) expressed in baculovirus infected Sf9 cells after 30 mins by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.36 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4646073 | — | — | 1 | 6.82 |
| CHEMBL4640734 | — | — | 1 | 6.60 |
| CHEMBL4644523 | — | — | 1 | 6.43 |
| CHEMBL4077392 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4646073 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4640734 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL4644523 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL4077392 | — | IC50 | = | 2699.0 | nM | 5.57 |