Assay Detail
Functional
CHEMBL4619353
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by Celltiter-Glo assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.68 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447340 | — | — | 1 | 9.52 |
| CHEMBL4649161 | — | — | 1 | 9.18 |
| CHEMBL4646522 | — | — | 1 | 9.09 |
| CHEMBL4644074 | — | — | 1 | 9.08 |
| CHEMBL4633886 | — | — | 1 | 9.05 |
| CHEMBL4640902 | — | — | 1 | 8.89 |
| CHEMBL4644486 | — | — | 1 | 8.82 |
| CHEMBL4635493 | — | — | 1 | 8.82 |
| CHEMBL4528514 | — | — | 1 | 8.80 |
| CHEMBL4645364 | — | — | 1 | 8.77 |
| CHEMBL4640074 | — | — | 1 | 8.74 |
| CHEMBL4648503 | — | — | 1 | 8.64 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 8.59 |
| CHEMBL4644611 | — | — | 1 | 8.57 |
| CHEMBL4641732 | — | — | 1 | 8.52 |
| CHEMBL4638997 | — | — | 1 | 8.25 |
| CHEMBL4634404 | — | — | 1 | 8.19 |
| CHEMBL4641773 | — | — | 1 | 8.07 |
| CHEMBL3581693 | BRILANESTRANT | 2.0 | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447340 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4649161 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL4646522 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL4644074 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL4633886 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4640902 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4644486 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4635493 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4528514 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4645364 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4640074 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4648503 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4644611 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4641732 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4638997 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4634404 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4641773 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3581693 | BRILANESTRANT | IC50 | = | 44.0 | nM | 7.36 |