Assay Detail
Functional
CHEMBL4619458
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Antiproliferative activity against human SW480 cells incubated for 72 hrs by CCK8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.56 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635027 | — | — | 1 | 5.16 |
| CHEMBL4647310 | — | — | 1 | 5.10 |
| CHEMBL4641483 | — | — | 1 | 4.92 |
| CHEMBL4646627 | — | — | 1 | 4.82 |
| CHEMBL4649810 | — | — | 1 | 4.77 |
| CHEMBL4635450 | — | — | 1 | 4.58 |
| CHEMBL1387422 | — | — | 1 | 4.25 |
| CHEMBL4642256 | — | — | 1 | 4.24 |
| CHEMBL4644891 | — | — | 1 | 4.16 |
| CHEMBL4648416 | — | — | 1 | 4.12 |
| CHEMBL4636954 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635027 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4647310 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4641483 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4646627 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4649810 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4635450 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1387422 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL4642256 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL4644891 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4648416 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL4636954 | — | IC50 | = | 81000.0 | nM | 4.09 |