Assay Detail
Binding
CHEMBL4619652
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Binding affinity to His-tagged recombinant human HDAC8 by SPR assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 7.79 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170177 | — | — | 1 | 8.51 |
| CHEMBL4642821 | — | — | 1 | 8.46 |
| CHEMBL4643684 | — | — | 1 | 8.11 |
| CHEMBL4638505 | — | — | 1 | 8.10 |
| CHEMBL4649651 | — | — | 1 | 8.08 |
| CHEMBL4649867 | — | — | 1 | 8.07 |
| CHEMBL4637226 | — | — | 1 | 8.01 |
| CHEMBL4637798 | — | — | 1 | 7.97 |
| CHEMBL4640819 | — | — | 1 | 7.62 |
| CHEMBL4649514 | — | — | 1 | 7.58 |
| CHEMBL4642398 | — | — | 1 | 7.58 |
| CHEMBL4641613 | — | — | 1 | 7.43 |
| CHEMBL4643791 | — | — | 1 | 7.34 |
| CHEMBL4640536 | — | — | 1 | 7.02 |
| CHEMBL4642047 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170177 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL4642821 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL4643684 | — | Kd | = | 7.7 | nM | 8.11 |
| CHEMBL4638505 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL4649651 | — | Kd | = | 8.4 | nM | 8.08 |
| CHEMBL4649867 | — | Kd | = | 8.48 | nM | 8.07 |
| CHEMBL4637226 | — | Kd | = | 9.81 | nM | 8.01 |
| CHEMBL4637798 | — | Kd | = | 10.8 | nM | 7.97 |
| CHEMBL4640819 | — | Kd | = | 23.9 | nM | 7.62 |
| CHEMBL4649514 | — | Kd | = | 26.1 | nM | 7.58 |
| CHEMBL4642398 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL4641613 | — | Kd | = | 37.5 | nM | 7.43 |
| CHEMBL4643791 | — | Kd | = | 45.9 | nM | 7.34 |
| CHEMBL4640536 | — | Kd | = | 94.7 | nM | 7.02 |
| CHEMBL4642047 | — | Kd | = | 95.1 | nM | 7.02 |