Assay Detail
Binding
CHEMBL4619653
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Binding affinity to human HDAC8 pre-incubated for 10 mins before FITC-M344 addition and measured after 10 mins by fluorescence polarization assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.79 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642398 | — | — | 1 | 7.92 |
| CHEMBL4637226 | — | — | 1 | 7.48 |
| CHEMBL4649651 | — | — | 1 | 7.38 |
| CHEMBL4637798 | — | — | 1 | 7.23 |
| CHEMBL4640205 | — | — | 1 | 7.22 |
| CHEMBL4643684 | — | — | 1 | 7.20 |
| CHEMBL4649867 | — | — | 1 | 7.14 |
| CHEMBL4642047 | — | — | 1 | 6.97 |
| CHEMBL4642821 | — | — | 1 | 6.95 |
| CHEMBL4640819 | — | — | 1 | 6.93 |
| CHEMBL2170177 | — | — | 1 | 6.88 |
| CHEMBL4641613 | — | — | 1 | 6.84 |
| CHEMBL4649514 | — | — | 1 | 6.69 |
| CHEMBL4641253 | — | — | 1 | 6.58 |
| CHEMBL4643791 | — | — | 1 | 6.47 |
| CHEMBL4633998 | — | — | 1 | 6.45 |
| CHEMBL4633453 | — | — | 1 | 6.43 |
| CHEMBL4640536 | — | — | 1 | 6.26 |
| CHEMBL4641390 | — | — | 1 | 6.14 |
| CHEMBL4639383 | — | — | 1 | 5.98 |
| CHEMBL4646090 | — | — | 1 | 5.52 |
| CHEMBL4634713 | — | — | 1 | - |
| CHEMBL4638505 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642398 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL4637226 | — | IC50 | = | 32.8 | nM | 7.48 |
| CHEMBL4649651 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL4637798 | — | IC50 | = | 58.7 | nM | 7.23 |
| CHEMBL4640205 | — | IC50 | = | 59.6 | nM | 7.22 |
| CHEMBL4643684 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL4649867 | — | IC50 | = | 72.8 | nM | 7.14 |
| CHEMBL4642047 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4642821 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4640819 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL2170177 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4641613 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4649514 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL4641253 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL4643791 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4633998 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL4633453 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL4640536 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL4641390 | — | IC50 | = | 727.0 | nM | 6.14 |
| CHEMBL4639383 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4646090 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4634713 | — | IC50 | - | — | - | |
| CHEMBL4638505 | — | IC50 | - | — | - |